Pre-treatment Apparent Diffusion Coefficient Does Not Predict Therapy Response to Radiochemotherapy in Cervical Cancer: A Systematic Review and Meta-analysis

Background/Aim: Magnetic resonance imaging is used for staging purposes in cervical cancer (CC). Diffusion-weighted and the apparent diffusion coefficient (ADC) are associated with tumor microstructure. The present analysis sought to compare pre-treatment ADC values predict treatment outcome of radiochemotherapy CC based upon a large patient sample. Materials Methods: MEDLINE library SCOPUS databases were assessed suitable articles up May 2020. primary endpoint was mean value according response radiochemotherapy. In total, 16 studies included analysis. Results: For group, 416 patients (72.5%) no-response group 158 (27.5%). 0.87×10−3 mm2/s (95% confidence interval=0.81-0.94×10−3 mm2/s), no 0.92×10−3 interval=0.85-0.98×10−3 mm2/s). Conclusion: Pre-treatment alone cannot be reliably CC.